Publikácie

Rok 2009

• Auton M., Sedlák E., Marek J., Wu T., Zhu C., Cruz M.A.: Changes in thermodynamic stability of von Willebrand factor differentially affect the force-dependent binding to platelet GPIbalpha. Biophys J. 97(2) (2009) 618-27.
• Sedlák E., Fedunová D., Veselá V., Sedláková D., Antalík M.: Polyanion hydrophobicity and protein basicity affect protein stability in protein-polyanion complexes. Biomacromolecules. 10(9) (2009) 2533-8.
• Sedlák E., Robinson N.C.: Sequential dissociation of subunits from bovine heart cytochrome C oxidase by urea. Biochemistry. 48(34) (2009) 8143-50.
• Droghetti E., Sumithran S., Sono M., Antalík M., Fedurco M., Dawson J.H., Smulevich G.: Effects of urea and acetic acid on the heme axial ligation structure of ferric myoglobin at very acidic pH. Arch Biochem Biophys. 489(1-2) (2009) 68-75.
• Bedlovičová Zdenka, Imrich Ján, Kristian Pavol, Danihel Ivan, Böhm Stanislav, Sabolová Danica, Kožurková Mária, Pauliková Helena, Klika Karel D.: Novel carbohydrazide and hydrazone biomarkers based on 9-substituted acridine and anthracene fluorogens. Heterocycles. (2009) in press
• Varháč R., Tomášková N., Fabián M., Sedlák E. (2009) Kinetics of cyanide binding as a probe of local stability/flexibility of cytochrome c, Biophysical Chemistry 144, 21-26.
• Vantová Zuzana, Paulíková Helena, Sabolová Danica, Kožurková Mária, Sucháňová Mária, Janovec Ladislav, Kristian Pavol, Imrich Ján: Cytotoxic activity of acridin-3,6-diyldithiourea hydrochlorides in human leukemia line HL60 and in resistant subline HL60/ADR. International Journal of Biological Macromolecules. 45 (2009) 174-180.
• Valušová E., Svec P., Antalík M. (2008) Structural and thermodynamic behavior of cytochrome c assembled with glutathione-covered gold nanoparticles. J Biol Inorg Chem. 14(4) (2009) 621-30.
• Weininger U., Haupt C., Schweimer K., Graubner W., Kovermann M., Bruser T., Scholz C., Schaarschmidt P., Žoldák G., Schmid FX., Balbach J. (2009) NMR Solution Structure of SlyD from Escherichia coli: Spatial Separation of Prolyl Isomerase and Chaperone Function. Journal of Molecular Biology 387(2) (2009) 295-305.
• Žoldák G., Carstensen L., Scholz C., Schmid FX. (2009) Consequences of Domain Insertion on the Stability and Folding Mechanism of a Protein. Journal of Molecular Biology (In Press).
• Fröhlichová Zdenka, Tomaščiková Jana, Imrich Ján, Kristian Pavol, Danihel Ivan, Böhm Stanislav, Sabolová Danica, Kožurková Mária, Klika Karel D.: Synthesis and properties of novel biologically interesting polycyclic 1,3,4-oxadiazoles containing acridine/acridone moieties. Heterocycles. 77, 2 (2009), 1019-1035.
• Zdenka Fröhlichová, Ján Imrich, Pavol Kristian, Ivan Danihel, Stanislav Böhm, Danica Sabolová, Mária Kožurková, Oľga Hritzová, Branislav Horváth, Tatiana Bušová, Karel D. Klika: Spectroscopic, structural and theoretical studies of novel, potentially cytotoxic 4-acridonecarboxamide imines. Spectrochimica Acta 73 (2009) 238-248.
• Viglaský V. (2008) Platination of telomeric sequences and nuclease hypersensitive elements of human c-myc and PDGF-A promoters and their ability to form G-quadruplexes, FEBS J. 2009 Jan;276(2):401-9.

Rok 2008

• Poniková S., Antalík M., Hianik T. (2008) A circular dichroism study of the stability of guanine quadruplexes of thrombin DNA aptamers at presence of K(+) and Na(+) ions. Gen. Physiol. Biophys. 27 (4), 271-7.
• Bágeľová J., Fedunová D., Gažová Z., Fabian M., Antalík M. (2008) Influence of NaCl and sorbitol on the stability of conformations of cytochrome c. Biophys. Chem. 135 (1-3), 110-5.
• Gažová Z., Bellová A., Daxnerová Z., Imrich J., Kristian P., Tomaščíková J., Bágeľová J., Fedunová D., Antalík M. (2008) Acridine derivatives inhibit lysozyme aggregation. Eur. Biophys. J. 37 (7), 1261-70.
• Sedlák E., Ziegler L., Kossman D.J. & *Wittung-Stafshede P. (2008) In vitro unfolding of yeast multi-copper oxidase Fet3p variants reveals unique role of each metal site. Proc. Natl. Acad. Sci. U.S.A. 105, 19257-19262.
• Rodriguez-Granillo A., Sedlák E. & Wittung-Stafshede P. (2008) Stability and ATP binding of the nucleotide-binding domain of the Wilson disease protein: Effect of the common H1069Q mutation. J. Mol. Biol. 383, 1097-1111.
• Sedlák E., Stagg L. & Wittung-Stafshede P. (2008) Effect of Hofmeister ions on protein thermal stability: Role of ion hydration and peptide groups? Arch. Biochem. Biophys. 479(1), 69-73.
• Žoldák G., Sedlák E., Wolfrum A, Musatov A, Fedunová D, Szkaradkiewicz K, Sprinzl M. Multidomain Initiation Factor 2 from Thermus thermophilus Consists of the Individual Autonomous Domains, Biochemistry, 47(17):4992-5005.
• Sedlák E., Stagg L., Wittung-Stafshede P. (2008) Role of cations in stability of acidic protein Desulfovibrio desulfuricans apoflavodoxin, Arch Biochem Biophys. 474(1), 128-35
• Varhač R., Antalík M. (2008) Correlation of acid-induced conformational transition of ferricytochrome c with cyanide binding kinetics, J Biol Inorg Chem. 2008 Mar 4, 13(5), 713-721.
• Tóth K., Sedlák E., Sprinzl M., Žoldák G. (2008) Flexibility and enzyme activity of NADH oxidase from Thermus thermophilus in the presence of monovalent cations of Hofmeister series, Biochim Biophys Acta. 1784(5):789-95.
• Kožurková M., Sabolová D., Janovec L., Mikeš J., Kovaľ J., Ungvarský J., Štefanišinová M., Fedoročko P., Kristián P., Imrich J.(2008) Cytotoxic activity of proflavine diureas: Synthesis, antitumor, evaluation and DNA binding properties of 1´,1´´-(acridin-3,6-diyl)-3´,3´´-dialkyldiureas, Bioorganic & Medicinal Chemistry, 16(7):3976-3984.
• Sedlák E., Žoldák G., Wittung-Stafshede P. (2008) Role of Copper in Thermal Stability of Human Ceruloplasmin, Biophysical Journal, 94(4): 1384-1391.

Rok 2007

• Sedlák E. & *Wittung-Stafshede P. (2007) Discrete Roles of Copper Ions in Chemical Unfolding of Human Ceruloplasmin. Biochemistry 46(33), 9638-9644.
• Hussain F.,Sedlák E.,Wittung-Stafshede P. Role of copper in folding and stability of cupredoxin-like copper-carrier protein CopC, Archives of Biochemistry and Biophysics, 2007, 467: 58-66.
• Bajdichová M., Pauliková H., Jakubiková J., Sabolová D. Comparison of inhibition of murine leukaemia cell growth by 9-isothiocyanatoacridine and its cytosine adduct: involvement of thiols, Neoplasma 54, 6, 2007 (in press)
• Kožurková M., Sabolová D., Paulíková H., Janovec L., Kristián P., Bajdichová M., Buša J., Podhradský D., Imrich J. DNA binding properties and evaluation of cytotoxic activity of 9,10-bis-N-substituted (aminomethyl)anthracenes International Journal of Biological Macromolecules, 2007 Oct 1;41(4):415-22.
• Kožurková M., Letavayová L., Mišúrová E. Influence of gamma irradiation on DNA methylation in liver of male rats and their offspring, Acta Veterinaria Brno 2007, 76,279-286.
• Staničová J., Sedlák E., Musatov A., Robinson N.C. Differential Stability of Dimeric and Monomeric Cytochrome c Oxidase Exposed to Elevated Hydrostatic Pressure, Biochemistry. 2007 Jun 19;46(24):7146-52.
• Sedlák E. Characterization of the polyanion-induced molten globule-like state of cytochrome c, Biopolymers. 2007 Jun 5;86(2):119-26.
• Zoldak G., Redecke L., Svergun D.I., Konarev P.V., Voertler C.S., Dobbek H., Sedlak E., Sprinzl M. Release Factors 2 from Escherichia coli and Thermus thermophilus: structural, spectroscopic and microcalorimetric studies. Nucleic Acids Res. 2007 Feb 1,35(4):1343-53.
• Tomášková N., Varhač R., Žoldák G., Olekšáková L., Sedláková D., Sedlák E. Conformational stability and dynamics of cytochrome c affect its alkaline isomerization. J Biol Inorg Chem 2007 Feb;12(2):257-66.
• Janovec L., Sabolová D., Kožurková M., Paulíková H., Kristian P., Ungvarský J., Moravčíková E., Bajdichová M., Podhradský D., Imrich J. Synthesis, DNA interaction, and cytotoxic activity of a novel proflavine-dithiazolidinone pharmacophore, Bioconjugate Chem 2007 Jan 17;18(1):93-100.
• Viglasky V., Danko P. Intercalators:Contra cruciform extrusion in DNA, Anal. Biochem, 2007 Jan 1;360(1):7-13.

Rok 2006

• Adamcik J., Klinov D.V., Witz G., Sekatskii S.K., Dietler G. Observation of single-stranded DNA on mica and highly oriented pyrolytic graphite by atomic force microscopy, FEBS Lett. 2006 Oct 16; 580(24), 5671-5675
• Viglasky V. Anthracyclines-contra cruciform extrusion in DNA regulating sequences,Endocrine, Metabolic and Immune Disorders - Drug Targets Sep 2006; 6(3),295-302
• Sabolova D, Kozurkova M, Kristian P, Danihel I, Podhradsky D, Imrich J. Determination of the binding affinities of plasmid DNA using fluorescent intercalators possessing an acridine skeleton. Int J Biol Macromol. 2006 Mar 30;38(2):94-8.
• Žoldák G., *Sedlák E., Valušová E., Wolfrum A., Marek J., Antalík M., Sprinzl M. Irreversible thermal denaturation of elongation factor Ts from Thermus thermophilus. Effect of the residual structure and intermonomer disulphide bond. Biochim. Biophys. Acta 2006; 1764, 1277-1285.
• Hritz J., Žoldák G., *Sedlák E. Cofactor assisted gating mechanism in the active site of NADH oxidase from Thermus thermophilus. Proteins 2006; 64(2), 465-476.
• Arbach H, Viglasky V, Lefeu F, Guinebretiere JM, Ramirez V, Bride N, Boualaga N, Bauchet T, Peyrat JP, Mathieu MC, Mourah S, Podgorniak MP, Seignerin JM, Takada K, Joab I. Epstein-Barr virus (EBV) genome and expression in breast cancer tissue: effect of EBV infection of breast cancer cells on resistance to paclitaxel (Taxol). J Virol. 2006 Jan;80(2):845-53.
• Mikulášová D, Tomášková N, Maderová J, Kollárová M. Crystallization and preliminary diffraction studies of malate dehydrogenase from Streptomyces aureofaciens. Prot.& Pept. Letters 2006;13:207-210.
• Sedlak E, Panda M, Dale MP, Weintraub ST, Robinson NC. Photolabeling of Cardiolipin Binding Subunits within Bovine Heart Cytochrome c Oxidase. Biochemistry. 2006 Jan 24;45(3):746-54.
• Stupak M, Zoldak G, Musatov A, Sprinzl M, Sedlak E. Unusual effect of salts on the homodimeric structure of NADH oxidase from Thermus thermophilus in acidic pH. Biochim Biophys Acta. 2006 Jan;1764(1):129-37.

Rok 2005

• Danko P, Kozak A, Podhradsky D, Viglasky V. Analysis of DNA intercalating drugs by TGGE. J Biochem Biophys Methods. 2005 Dec 31;65(2-3):89-95.
• Viglasky V, Danko P, Adamcik J, Valle F, Dietler G. Detection of cruciform extrusion in DNA by temperature-gradient gel electrophoresis. Anal Biochem. 2005 Aug 15;343(2):308-12.
• Piknova M, Filova M, Javorsky P, Pristas P. A unique pair of GATC specific DNA methyltransferases in Mitsuokella multiacida. Mol Biol Rep. 2005 Dec;32(4):281-4.
• Mrázek J, Piknová M, Pristaš P, Kopečný J. Occurrence of restriction-modification systems in ruminal butyrate-producing bacteria. Anaerobe 2005 11, 280-284.
• Pristas P, Piknova M. Underrepresentation of short palindromes in Selenomonas ruminantium DNA: evidence for horizontal gene transfer of restriction and modification systems? Can J Microbiol. 2005 Apr;51(4):315-8.
• Piknova M, Javorsky P, Pristas P. Multiple restriction-modification systems are present in rumen treponemes. FEMS Microbiol Lett. 2005 Oct 1;251(1):99-103.
• Zoldak G, Musatov A, Stupak M, Sprinzl M, Sedlak E. pH-induced changes in activity and conformation of NADH oxidase from Thermus hermophilus. Gen Physiol Biophys. 2005 Sep;24(3):279-98.
• Fedurco M, Augustynski J, Indiani C, Smulevich G, Antalik M, Bano M, Sedlak E, Glascock MC, Dawson JH. Electrochemistry of unfolded cytochrome c in neutral and acidic urea solutions. J Am Chem Soc. 2005 May 25;127(20):7638-46.

Rok 2004

• Fedurco M., Augustynski J., Indiani C., Smulevich G., Antalík M., Bánó M., Sedlák E., Glascock M.C. & Dawson J.H. The heme iron coordination structure of unfolded ferric and ferrous cytochrome c in neutral and acidic urea solutions. Spectroscopic and electrochemical studies. Biochim Biophys Acta. 2004 Dec 1;1703(1):31-41.
• Piknová M., Pristaš P., Javorský P. Niektoré evolučné aspekty biológie restrikčno-modifikačných systémov II.typu. Biologické listy 2004 69(1), 15-28.
• Piknová M., Pristaš P., Javorský P. GATC-specific restriction-modification systems in ruminal bacteria. Folia Microbiol (Praha). 2004;49(2):191-3.
• Piknová M., Fiľová M., Javorský P., Pristaš P. Different restriction and modification phenotypes in ruminal lactate-utilizing bacteria. FEMS Microbiol Lett. 2004 Jul 1;236(1):91-5.
• Bánó M., Marek J., Stupák M. Hydrodynamic parameters of hydrated macromolecules: Monte Carlo calculation. Phys. Chem. Chem. Phys. 2004 6, 2358-2363.
• Kristian P., Balentová E., Bernát J., Imrich J., Sedlák E., Danihel I., Böhm S., Prónayová N., Klika D., Pihlaja K. & Baranová J. Fluorescence and Structure of Methylated Acridin-9-ylthioureas. Chemical Papers 2004 58(4), 268-275.
• Bernát J., Balentová E., *Kristian P., Imrich J., Sedlák E., Danihel I., Böhm S., Prónayová N., Pihlaja K., Klika D. Methylation of acridin-9-ylthioureas. Structure, fluorescence and biological properties of products. Collect. Czech. Chem. Commun. 2004 69, 833-849.
• Varhač R., *Antalík M. Determination of the pK for the Acid-Induced Denaturation of Ferrocytochrome c. Biochemistry 2004 43, 3564-3569.
• Zoldak G, Zubrik A, Musatov A, Stupák M, Sedlak E. Irreversible thermal denaturation of glucose oxidase from aspergillus niger is the transition to the denatured state with residual structure. J Biol Chem. 2004 Aug 31.
• Zoldak G, Sprinzl M, Sedlak E. Modulation of activity of NADH oxidase from Thermus thermophilus through change in flexibility in the enzyme active site induced by Hofmeister series anions. Eur J Biochem. 2004 Jan;271(1):48-57.
• Varhac R, Antalik M, Bano M. Effect of temperature and guanidine hydrochloride on ferrocytochrome c at neutral pH. J Biol Inorg Chem. 2004 Jan; 9(1): 12-22.

Rok 2003

• Zoldak G, Sutak R, Antalik M, Sprinzl M, Sedlak E. Role of conformational flexibility for enzymatic activity in NADH oxidase from Thermus thermophilus.Eur J Biochem. 2003 Dec;270(24):4887-4897.
• Viglaský V, Valle F, Adamčík J, Joab I, Podhradsky D, Dietler G. Anthracycline-dependent heat-induced transition from positive to negative supercoiled DNA. Electrophoresis. 2003 Jun;24(11):1703-11.
• Antalik M, Bagelova J, Gazova Z, Musatov A, Fedunova D. Effect of varying polyglutamate chain length on the structure and stability of ferricytochrome c. Biochim Biophys Acta. 2003 Mar 21;1646(1-2):11-20.

Rok 2002

• Minarik P, Tomaskova N, Kollarova M, Antalik M. Malate dehydrogenases--structure and function. Gen Physiol Biophys 2002 Sep;21(3):257-65
• Adamčík J, Viglaský V, Valle F, Antalík M, Podhradský D, Dietler G. Effect of bacteria growth temperature on the distribution of supercoiled DNA and its thermal stability. Electrophoresis. 2002 Sep;23(19):3300-9.
• Sedlák E., Antalík M. Effect of polyanion on the acidic conformational transition of native and denatured ferricytochrome c. Circular Dichroism study. General Physiology and Biophysics. 2002 Jun; 21(2):175-88.
• Perl D, Jacob M, Bano M, Stupák M, Antalík M, Schmid FX. Thermodynamics of a diffusional protein folding reaction. Biophys Chem. 2002 May 2;96(2-3):173-90.
• Sedlák E, Žoldák G, Antalík M, Sprinzl M. Thermodynamic properties of nucleotide-free EF-Tu from Thermus thermophilus in the presence of low-molecular weight effectors of its GTPase activity. Biochim. Biophys. Acta-Protein Structure and Molecular enzymology. 2002 May 20; 1597(1):22-27.
• Sedlák E, Sprinzl M, Grillenbeck N, Antalík M. Microcalorimetric study of elongation factor Tu from Thermus thermophilus in nucleotide-free, GDP and GTP forms and in the presence of elongation factor Ts. Biochim. Biophys. Acta-Protein Structure and Molecular enzymology. 2002 Apr. 29; 1596(2):357-365.
• Janovec L, Suchár G, Imrich J, Kristian P, Sasinková V, Alföldi J, Sedlák E. 9-isothiocyanatoanthracene as a versatile starting compound in the chemistry of anthracen-9-yl derivatives. Collect. Czech. Chem. Commun. 2002; 67, 665-678.

Rok 2001

• Sedlák E., Valušová E., Nesper-Brock, M., Antalík M., Sprinzl M., Effect of the central disulfide bond on the unfolding behavior of Elongation factor Ts from Thermus thermophilus. Biochemistry 2001 Aug 14; 40(32):9579-9586.
• Valušová E., Sedlák E., Antalík M., Nock S., Sprinzl M., Effect of N-domain on the stability of elongation factor Ts from Thermus thermophilus. Biochim. Biophys. Acta-Protein Structure and Molecular enzymology 2001 May 5;1547(1):117-126.
• Kristián P., Bernát J., Imrich J., Sedlák E., Alföldi J., Čornanič M., New approach to synthesis of N-substituted 9-amino/iminoacridines with important fluorescence properties. Heterocycles 2001; 55(2), 279-290.

Rok 2000

• Jamin M, Antalik M, Loh SN, Bolen DW, Baldwin RL.,The unfolding enthalpy of the pH 4 molten globule of apomyoglobin measured by isothermal titration calorimetry. Protein Sci. 2000 Jul;9(7):1340-6.
• Viglasky V, Antalik M, Adamcik J, Podhradsky D., Early melting of supercoiled DNA topoisomers observed by TGGE. Nucleic Acids Res. 2000 Jun 1;28(11):E51.
• Viglasky V, Antalik M, Bagelova J, Tomori Z, Podhradsky D., Heat-induced conformational transition of cytochrome c observed by temperature gradient gel electrophoresis at acidic pH. Electrophoresis. 2000 Mar;21(5):850-8.

Rok 1999

• Sedlák E, Robinson NC., Phospholipase A(2) digestion of cardiolipin bound to bovine cytochrome c oxidase alters both activity and quaternary structure. Biochemistry. 1999 Nov 9;38(45):14966-72.
• Sedlak E, Antalik M., Molten globule-like state of cytochrome c induced by polyanion poly(vinylsulfate) in slightly acidic pH. Biochim Biophys Acta. 1999 Oct 12;1434(2):347-55.
• Gazova Z, Antalik M, Bagelova J, Tomori Z., Effect of ionic strength on the interfacial properties of cytochrome c. Biochim Biophys Acta. 1999 Jun 15;1432(1):82-91.

Rok 1998

• Nesper M, Nock S, Sedlak E, Antalik M, Podhradsky D, Sprinzl M., Dimers of Thermus thermophilus elongation factor Ts are required for its function as a nucleotide exchange factor of elongation factor Tu. Eur J Biochem. 1998 Jul 1;255(1):81-6.
• Mikulasova D, Kollarova M, Miginiac-Maslow M, Decottignies P, Jacquot JP, Kutejova E, Mernik N, Egyudova I, Musrati R, Horecka T., Purification and characterization of the malate dehydrogenase from Streptomyces aureofaciens. FEMS Microbiol Lett. 1998 Feb 15;159(2):299-305.
• Sedlák E., Antalík M. (1998). Coulombic and Noncoulombic Effect of Polyanions on Cytochrome c Structure. Biopolymers 46(3), 145-154.
• Paulikova H, Molnarova M, Podhradsky D. The effect of heparin and pentosan polysulfate on the thermal stability of yeast alcohol dehydrogenase. Biochem Mol Biol Int. 1998 Dec;46(5):887-94.

Rok 1997

• Sedlak E, Antalik M, Bagelova J, Fedurco M., Interaction of ferricytochrome c with polyanion Nafion. Biochim Biophys Acta. 1997 Apr 11;1319(2-3):258-66.